Selank is a synthetic peptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences, and it has garnered interest for its anxiolytic, nootropic, and neuroprotective properties. It is structurally derived from the naturally occurring tetrapeptide tuftsin, which is involved in immune modulation, and Selank has been modified to enhance stability and activity.

Researchers exploring Selank have noted its potential to positively influence neurotransmitter balance, memory, anxiety levels, and immune response. Though not yet approved by Western regulatory bodies like the FDA or TGA, Selank is approved in Russia for clinical use under specific guidelines.

This product is sold for laboratory research use only and is not for human consumption. It comes in lyophilized powder form for reconstitution and testing under sterile, controlled conditions.

Mechanism of Action:

Selank is a synthetic heptapeptide with the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It operates primarily through interaction with the GABAergic and serotonergic systems, modulating neurotransmitter release and reuptake. Key proposed mechanisms include:

• Stimulation of GABA receptors

• Inhibition of enkephalin-degrading enzymes

• Stabilization of serotonin levels

• Upregulation of brain-derived neurotrophic factor (BDNF)

• Regulation of dopamine and norepinephrine release

By working through these systems, Selank may produce calming, cognition-enhancing, and mood-regulating effects in animal models.

Theoretical Benefits of Selank:

All effects listed are based on preclinical and clinical research and are not approved indications. Selank is offered for research use only.

1. Anxiolytic (Anti-Anxiety) Effects:

Selank has shown significant promise as a non-sedating anxiolytic. In animal models and limited human trials, Selank reduced anxiety and stress-induced behaviors without the side effects commonly associated with benzodiazepines, such as drowsiness or dependency.

2. Nootropic (Cognitive Enhancement):

Selank may improve attention, memory, and information processing speed. It has been proposed to enhance BDNF expression, which is critical for synaptic plasticity, learning, and memory retention. These effects have made it popular in nootropic research.

3. Neuroprotection and Mood Stabilization:

Studies suggest Selank helps regulate neurochemical imbalances, offering potential benefits in research on depression, chronic fatigue, and PTSD. It may also reduce oxidative stress in brain tissue and protect against neurological damage.

4. Immune Modulation:

Tuftsin analogues like Selank have demonstrated immunomodulatory properties. Selank has been shown to increase the expression of interferon gamma and other key immune markers, making it a candidate for research into infection resistance and autoimmune support.

5. Improved Sleep Quality:

In some animal studies, Selank helped normalize circadian rhythms and promote deeper sleep without sedative effects. This supports its potential role in research targeting sleep disorders or sleep-related mood disturbances.

Research Studies and Clinical Data:

• Russian Clinical Trials: Selank has undergone several clinical trials in Russia. In one study, patients with generalized anxiety disorder (GAD) who received Selank reported reduced anxiety comparable to diazepam, without sedation or withdrawal symptoms.

• Cognitive Benefits: Research published in “Bulletin of Experimental Biology and Medicine” indicated Selank improved cognitive function and restored memory performance in rats subjected to stress or neurotoxin exposure.

• Neurotransmitter Studies: Selank was found to stabilize levels of serotonin and dopamine in animal models, suggesting its use as a modulator for mood and motivation.

• Immune Research: A study in “Neurochemical Journal” showed Selank increased IL-6 and TNF-alpha expression, pointing toward a pro-inflammatory immune balancing role during acute stress.

Theoretical Research Dosage:

• Common Lab Dose: 250–500mcg per day in rodent models

• Typical Duration: 10–14 days for acute effects, 4–6 weeks for chronic studies

• Reconstitution: Reconstitute 10mg Selank with 2mL bacteriostatic water for 5mg/mL solution

• Storage: Store lyophilized powder in fridge (2–8°C). Once reconstituted, use within 30 days refrigerated.

Side Effects in Research Models:

Selank has demonstrated a very favorable safety profile in both animal and limited human studies:

• No sedation

• No withdrawal or dependency potential

• Minimal to no side effects reported

• In high doses, mild irritability or headaches were reported in a small number of cases

Unlike benzodiazepines, Selank does not interact with alcohol, nor does it cause impairment in psychomotor function.

Legal and Safety Disclaimer:

Selank is not approved for medical or therapeutic use. It is provided strictly for laboratory research and must only be handled by qualified personnel in appropriate environments. It is the responsibility of the buyer to comply with all local laws governing possession, use, and import of research chemicals.