RAD-140, commonly referred to as Testolone, is a highly selective androgen receptor modulator (SARM) developed to mimic the effects of anabolic steroids while avoiding many of their unwanted side effects. This compound has gained significant interest in research communities studying muscle wasting, neuroprotection, bone density, and testosterone replacement therapy alternatives.

As a non-steroidal SARM, RAD-140 offers strong anabolic effects without converting to DHT or estrogen, and without significantly impacting prostate size or liver enzymes in preclinical studies. Its exceptional anabolic-to-androgenic ratio makes it one of the most potent SARMs on the market.

This compound is intended for laboratory research purposes only. It is not approved for human consumption and is sold strictly for non-therapeutic, non-supplemental use.

What is RAD-140?

RAD-140 (Testolone) is a synthetic selective androgen receptor modulator that binds with high affinity to androgen receptors in muscle and bone tissue, but minimally affects other organs like the prostate, skin, or brain. This selectivity makes RAD-140 a leading candidate for testosterone replacement research, with promising anabolic potential and minimal suppressive drawbacks.

In rodent and primate models, RAD-140 has shown the ability to increase lean mass, improve strength, and support neuroprotection, all while avoiding common side effects associated with traditional anabolic agents.

Mechanism of Action:

RAD-140 works by selectively binding to androgen receptors located in skeletal muscle, bones, and other targeted tissues. Once bound, it activates anabolic signaling pathways, triggering muscle protein synthesis and bone mineralization.

However, unlike traditional androgens like testosterone, RAD-140 does not convert to estrogen or dihydrotestosterone (DHT). This avoids common issues like gynecomastia, water retention, or prostate enlargement, making it a clean model for androgenic research with fewer confounding variables.

Research Applications:

RAD-140 is for academic or laboratory use only. It is not a dietary supplement, medication, or treatment for any medical condition.

1. Muscle Wasting and Lean Mass Preservation:

RAD-140 has demonstrated powerful anti-catabolic effects in studies on muscle atrophy. In primate models, researchers observed dose-dependent increases in lean body mass over short periods, even without resistance training. This makes RAD-140 a prime subject for studying sarcopenia and cachexia.

2. Strength & Performance Enhancement:

RAD-140 improves force output and muscle strength via direct androgenic signaling in muscle cells. While it is not approved for human use, anecdotal research reports and experimental data suggest improved training intensity, muscle recovery, and athletic performance in observed subjects.

3. Neuroprotection and Brain Health:

One of the most unique aspects of RAD-140 is its ability to cross the blood-brain barrier and exert neuroprotective effects. Preclinical research shows it can shield brain neurons from amyloid beta toxicity, making it of interest in studies related to neurodegenerative diseases like Alzheimer’s.

4. Bone Density Enhancement:

RAD-140 promotes osteoblast activity (bone formation) and slows osteoclast breakdown. This leads to increased bone mineral density and improved skeletal integrity. It is being studied as a treatment alternative to osteoporosis therapies in aging populations.

Theoretical Benefits (Based on Preclinical and Anecdotal Evidence):

• Promotes rapid lean muscle growth

• Increases strength, endurance, and stamina

• Improves protein synthesis and nitrogen retention

• Supports fat loss via improved metabolism

• Enhances recovery between training sessions

• Exhibits neuroprotective properties

• Does not aromatize or convert to DHT

• Potential alternative to testosterone therapy

Suggested Dosage (For Research Use Only):

• Capsules per Bottle: 30 x 20mg

• Typical Research Range: 10–30mg per day

• Cycle Length: 6–10 weeks (experimental protocol)

• Half-Life: ~20 hours

• Daily dosing is generally sufficient.