Melanotan II (MT2) is a synthetic analog of the naturally occurring melanocortin peptide hormone alpha-melanocyte-stimulating hormone (α-MSH). It is best known for its ability to stimulate melanin production, making it the subject of research into tanning, photoprotection, and skin pigmentation. However, MT2 also exhibits potential effects on libido, appetite, and fat metabolism, owing to its activity on various melanocortin receptors throughout the body.

Originally developed as a potential treatment for skin cancer by increasing natural melanin levels, MT2 is widely studied today for its broad spectrum of physiological effects in laboratory settings. These include increased pigmentation, reduction in UV-induced skin damage, suppression of appetite, and enhanced sexual function.

This product is for laboratory research purposes only. It is not for human consumption or use as a drug, supplement, or cosmetic.

What is Melanotan II?

Melanotan II is a synthetic peptide that mimics the action of alpha-MSH, a naturally occurring hormone involved in regulating skin pigmentation, energy homeostasis, and sexual arousal. It binds to several melanocortin receptors (MC1R–MC5R), which are found in the skin, brain, and other tissues.

The peptide’s unique ability to activate multiple melanocortin pathways is the reason researchers study it for diverse outcomes: melanin stimulation for tanning, fat metabolism, mood, and even sexual arousal.

Scientific Studies & Research Applications:

All uses below are based on preclinical studies, animal models, and limited human research. This compound is not approved for clinical use.

1. Melanin Production & Skin Pigmentation:

MT2’s most well-documented function is inducing skin pigmentation by stimulating melanogenesis in melanocytes. This darkens the skin without the need for prolonged UV exposure.

• A clinical trial published in The New England Journal of Medicine (1998) found that MT2 significantly increased skin pigmentation in healthy male subjects over a short course of treatment.

• It has been proposed as a preventive agent for individuals prone to sunburn or at high risk of melanoma due to its ability to boost melanin and offer natural photoprotection.

2. Photoprotection & DNA Repair:

By enhancing melanin synthesis, Melanotan II may also protect skin cells against UV-induced DNA damage. Melanin acts as a natural sunscreen, absorbing harmful UV radiation.

• Research in mice has shown that MT2 treatment before UV exposure reduces sunburn and DNA photodamage markers.

• This makes it of interest in labs studying skin cancer prevention and UV resistance.

3. Sexual Arousal and Erectile Function:

MT2 binds to melanocortin receptors in the brain, particularly MC4R, which are involved in sexual behavior.

• In a 2000 Journal of Urology study, MT2 was found to induce spontaneous erections in healthy male volunteers.

• The compound is often compared to PT-141 (Bremelanotide), which is derived from MT2 and has FDA approval for female hypoactive sexual desire disorder (HSDD).

4. Appetite Suppression and Weight Loss:

Researchers have also found that MT2 can influence energy balance and food intake by interacting with MC3R and MC4R receptors.

• Animal studies demonstrate reduced caloric intake and increased fat oxidation in MT2-treated subjects.

• This has made it a topic of interest in obesity and appetite-regulation studies.

Mechanism of Action:

Melanotan II activates melanocortin receptors, which are G protein-coupled receptors responsible for regulating a wide range of biological functions. These include:

• MC1R – Stimulates melanogenesis (skin pigmentation)

• MC3R & MC4R – Involved in appetite suppression and libido regulation

• MC5R – May be linked to sexual performance and glandular secretion

Its ability to interact with multiple receptor types leads to its multi-functional profile, making MT2 one of the most versatile peptides studied in modern biomedical research.

Common Research Uses:

• UV resistance and tanning models

• Sexual behavior and arousal studies

• Weight loss and appetite regulation

• Skin cancer prevention research

• Photodamage reduction models

Reconstitution and Storage:

• Reconstitution: Use 1–2 mL of bacteriostatic water per 10mg vial.

• Storage (Lyophilized): Keep at 2–8°C in a dry, dark place.

• Storage (Reconstituted): Store refrigerated and use within 20–30 days for best integrity.

Reported Lab Observations:

While MT2 is generally well-tolerated in test environments, researchers have noted the following outcomes at various dosages:

• Rapid darkening of skin over several days or weeks

• Appetite reduction leading to decreased food intake

• Erections or heightened arousal in male animal models

• Mild nausea immediately following administration (dose dependent)

• Facial flushing and fatigue reported in some rodent studies

These observations are dose- and receptor-dependent and may vary based on the animal model and administration method.

Melanotan II vs. Alpha-MSH:

MT2 offers greater receptor affinity and a longer half-life than natural α-MSH, making it more potent and easier to work with in research settings. Its resistance to enzymatic breakdown in the body allows it to remain active longer, increasing its effectiveness in experimental designs.

Legal Status & Research Disclaimer:

Melanotan II is not approved for human or veterinary use by the FDA, TGA, or other governing bodies. It is sold strictly for research and laboratory use. This includes biochemical assays, in vitro studies, and receptor binding research.

Do not use this compound in food products, cosmetics, or pharmaceuticals. It is not for human consumption under any circumstance.