GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding peptide known for its potent regenerative, reparative, and anti-aging properties. In laboratory settings, GHK-Cu has demonstrated strong potential for tissue remodeling, wound healing, and skin regeneration, making it a leading candidate in cosmetic, dermatological, and anti-aging research.

First identified in human plasma in the 1970s, GHK-Cu plays an essential role in signaling repair and regeneration processes. It has been shown to upregulate collagen synthesis, promote angiogenesis, restore skin elasticity, and even modulate inflammation in damaged or aging tissue. GHK-Cu has also garnered attention for its potential in hair regrowth and skin rejuvenation studies.

This product is sold strictly for research purposes only and is not intended for human consumption or therapeutic use.

What is GHK-Cu?

GHK-Cu is a copper peptide — a small protein fragment naturally found in the human body that binds to copper ions. The GHK portion (glycyl-L-histidyl-L-lysine) has a high affinity for copper (Cu2+), allowing it to act as a carrier and signaling molecule.

As we age, natural GHK-Cu levels in the body decline. Research shows that GHK-Cu levels drop by over 60% by age 60, correlating with reduced skin repair, slower wound healing, and tissue degeneration. In cell culture and animal models, restoring GHK-Cu has been shown to reverse many markers of aging and oxidative stress.

Scientific Studies & Applications:

The following findings are based on laboratory studies, in vitro data, and animal models.

1. Collagen and Elastin Synthesis:

GHK-Cu is one of the few peptides shown to directly stimulate the production of collagen, elastin, glycosaminoglycans, and proteoglycans. These components form the building blocks of youthful skin and connective tissue.

• A landmark study published in Journal of Investigative Dermatology (1988) found GHK-Cu increased total collagen synthesis in skin fibroblast cultures by up to 70%.

2. Wound Healing and Tissue Remodeling:

GHK-Cu has a robust ability to accelerate wound closure, reduce inflammation, and rebuild dermal tissue. Studies on both human skin models and rodents demonstrate rapid granulation tissue formation and improved vascularization.

• In rat models, GHK-Cu significantly enhanced healing of full-thickness skin wounds and increased capillary formation.

3. Anti-Aging and Skin Tightening:

Topical application of GHK-Cu in cosmetic studies has shown visible improvements in skin firmness, clarity, and smoothness. Participants reported better elasticity, reduced sagging, and faded discoloration.

• One placebo-controlled study showed that a GHK-Cu cream reduced fine lines, improved skin thickness, and increased density over 12 weeks.

4. Hair Growth and Follicle Support:

GHK-Cu has been tested as a possible alternative or complement to Minoxidil in hair regrowth models. In vitro studies show it can stimulate dermal papilla cells, increase follicular blood flow, and prolong the anagen (growth) phase of the hair cycle.

• A 2007 double-blind clinical trial found that GHK-Cu spray improved hair count and density over 6 months with no reported side effects.

5. Anti-Inflammatory and Antioxidant Effects:

GHK-Cu has demonstrated broad-spectrum anti-inflammatory activity in cell and animal models. It inhibits pro-inflammatory cytokines like TNF-α, IL-6, and COX-2. It also activates antioxidant pathways, including the superoxide dismutase (SOD) enzyme system.

6. DNA Repair and Gene Modulation:

In recent genomic studies, GHK-Cu has been shown to upregulate over 400 human genes, particularly those involved in tissue remodeling, wound healing, and cellular defense. It also downregulates damaging genes involved in cancer, fibrosis, and inflammation.

• A 2010 bioinformatics study published in Rejuvenation Research found GHK-Cu restored youthful gene expression in aged human liver tissue samples.

7. Anti-Cancer Research Potential:

GHK-Cu has been shown in vitro to inhibit cancer cell proliferation and reduce metastasis-related gene expression. While far from conclusive, these results suggest potential as an adjunctive therapy or diagnostic agent in oncology models.

Reconstitution and Storage Guidelines:

• Reconstitution: Add 1–2 mL of bacteriostatic water per 100mg vial to achieve desired research concentration.

• Storage: Lyophilized GHK-Cu should be stored in a cool, dark place at 2–8°C. Reconstituted solution is stable for 20–30 days when refrigerated.

• Handling: Always use sterile techniques when preparing and storing peptide solutions for lab research.

Common Research Uses:

• Dermal repair models (burns, scars, aging)

• Hair follicle stimulation studies

• Cosmetic dermatology testing

• Tissue engineering and collagen remodeling

• Wound healing assays

• Anti-aging research

• Gene expression and DNA repair studies

TB-500 vs. GHK-Cu:

Both TB-500 and GHK-Cu are used in regenerative research, but they function via different mechanisms:

• TB-500 improves cellular movement and regeneration by modulating actin.

• GHK-Cu directly triggers collagen production and gene-level repair signals.

They are often studied together or in sequence for comprehensive soft tissue and skin repair.

Side Effects (Observed in Lab Settings):

GHK-Cu is considered extremely safe in all documented research. No toxicity or irritation was reported in animal models or topical studies on human skin. No systemic side effects were observed in oral or injectable trials.

Mild skin tingling, flushing, or sensitivity may occur at high topical concentrations in test environments.

Legal Status & Research Disclaimer:

GHK-Cu is not approved for human consumption or medical use. This product is for scientific research only. It has not been reviewed or evaluated by the TGA, FDA, or any health authority.